Association of social interaction with dementia among Chinese adults aged 65 years and older: A multicenter cross-sectional study
Hui Chen; Jiahui Xiang; Yu Cao; Chaohui Zhou; Duan Li; Yuan Li; Yong Ji; Shuai Liu*
The number of people developing dementia is expected to rapidly increase given the aging population. Effective treatments are lacking necessitating the development of intervention strategies to target modifiable risk factors.
Relationship between light-to-moderate alcohol consumption, serum cholesterol level, and dementia among community-living older adults aged ≥65 years in Tianjin, China
Hui Chen; Jiahui Xiang; Yu Cao; Chaohui Zhou; Duan Li; Yuan Li; Yong Ji; Shuai Liu*
To investigate the association between light-to-moderate alcohol consumption, serum cholesterol levels, and dementia incidence among community-dwelling older adults in Tianjin. A cross-sectional study of 3536 community-dwelling elderly (aged ≥65 years) in Tianjin from April to June 2019. Dementia was diagnosed using the International Classification of Diseases.
Smell function in patients with Parkinson’s disease can be expected to deteriorate over time
Alisa Vatashka; Thomas Hummel; Björn Falkenburger; Antje Haehner*
Olfactory dysfunction is one of the leading prodromal symptoms of Parkinson´s Disease (PD) [1], and has been investigated extensively in the past. However, hyposmia is generally considered a binary trait in manifest PD and less attention has been paid to the quantitative evolution of hyposmia after the clinical diagnosis of PD.
The brain and crime
Matthew Robinson, PhD*
This paper is a review paper examining relationships between the brain and crime. Based on a literature review from searches of two academic databases—ProQuest and Academic Search Complete—the paper summarizes what has been demonstrated about the brain and crime from the most recent peer-reviewed journal articles on the subject matter.
Evaluation of the effect of metenkephalin and tridecactid combination on corticotropic stimulation of the adrenal gland in patients with the relapsing- remitting form of multiple sclerosis
Burnazović-Ristić Lejla*; Maleškić Kapo S; Rakanović-Todić M; Aganović-Mušinović I; Mačkić-Đurović M; Šabanagić-Hajrić S; Suljić-Mehmedika E
The Relapsing-Remitting form of Multiple Sclerosis (RRMS) affects 85% of patients, characterized by alternating onset and remission of disease symptoms. The standard treatment for MS relapse is pulse corticosteroid therapy. In this study, the efficacy of a combination of neuropeptides (metenkephalin and tridecactid).
Common design elements in trials of cerebrospinal fluid diversion interventions in normal pressure hydrocephalus: A scoping review
Theres Alexander; Waliya Rahman; Sonali Vij; Manisha Koneru*
Normal Pressure Hydrocephalus (NPH) is a leading cause of reversible dementia in the elderly. Optimal treatment strategies, often diverting of Cerebrospinal Fluid (CSF), are an area of active investigation, as technology continues to advance. The advent of innovative shunting methods, such as the endovascularly placed shunts, holds potential to further improve outcomes.
The protein profiles in human brain structures underlying epileptic seizures
RH Ibadova; T Sh Rahimli; AA Mekhtiev*
The article is a pilot study that addresses the problem of molecular basis of epilepsy. The studies were carried out on the platelets, serum of the severe course epileptic patients and on the brain regions (hippocampus, amygdala and temporal cortex) removed from the epileptic patient’s during the appointed neurosurgery....
Flow diverter stent and conservative approaches in the management of giant serpentıne aneurysms: A series of six cases
Öyküm Akıncı, MD*; Ayşe Gülerl; Celal Çınar; Emre Kumral
Giant Serpentine Aneurysms (GSA) are rare vascular lesions characterized by partial thrombosis and a tortuous intra-aneurysmal flow channel, associated with high morbidity and mortality. This study presents six cases of serpentine aneurysms treated with Flow Diverter (FD) stents and compares the results with current literature....
Neurogenesis in deer antlers: Stem-cell-based development and regeneration
Wei Zhang; Shanmou Zhan; Litao Yan; Yuan Huang; Baolin Li; Lianjie Hou*
Deer antlers are the only mammalian accessory organs capable of complete annual regeneration, and they provide a unique model for studying neurogenesis and tissue regeneration. The process involves the coordinated regeneration of multiple tissue types, with nerves playing a pivotal role in sensory perception and in tissue function....
Exploring cerebrovascular dynamics following cortical spreading depolarization in an autologous intracerebral hemorrhage porcine model
Renán Sánchez-Porras; Francisco L Ramírez-Cuapio; Modar Kentar; Pablo Albiña-Palmarola; Marcos A Suárez-Gutiérrez; Angel Puig-Lagunes; Johannes Woitzik; Edgar Santos*; Bilal Younes*
Spreading Depolarization (SD) often emerges post-Intracerebral Hemorrhage (ICH). Autoregulation of cerebral blood flow and vascular reactivity can be impaired following SD. However, it is still unclear whether the association of SD and Cerebral Autoregulation (CA). We designed an exploratory study to investigate...
Minimally invasive diagnostics of alzheimer’s disease. The potential of using buccal cells
Alena Sidenkova*
The high prevalence of Alzheimer’s disease necessitates large-scale and affordable screening using minimally invasive biomarkers. This review aims to determine the potential value of buccal epithelium as a noninvasive biomarker of neurodenegeneration to further develop an accessible ...
Patient-centric multi-modal major depressive disorder detection
Sandura Shumba*; Johannes Coetzer
Major Depressive Disorder (MDD) remains a pressing global health issue, necessitating diagnostic models that effectively capture both neural and emotional cues. This study proposes a multi-modal framework that integrates generalised ...
The effectiveness and efficacy of stretching and proprioceptive neuromuscular facilitation on the context in spastic diplegic cerebral palsy children
Arup Kumar Borah*; Priyaka Goswami
Spasticity is a upper motor neuron disorder and can be seen in neurological conditions like and stroke and multiple sclerosis. Although the incidence rate of spasticity is unknown, it can put pressure on the health conditions
Combination of micronutrient mixture, probiotics, collagen peptides, omega 3, cannabidiol, and diet may reduce the risk of development and progression of Post-Traumatic Stress Disorder (PTSD), and improve its treatment
Kedar N Prasad*
Post-Traumatic Stress Disorder (PTSD) is a complex psychiatric disorder caused by sudden exposure to a single or repeated traumatic events. The major symptoms include flashbacks, nightmares, hyperarousal, depression, substance abuse, suicidal tendencies, impaired learning ability, and cognitive dysfunction.
The impact of Cognitive Reserve (CR) on the neuropsychological performance of pre-surgical patients with Temporal Lobe Epilepsy (TLE): A case series
Andrew D Lokai, PhD*; Evita Conway, MA; Heidi A Bender, PhD; Natalie Edman, MA; Jennifer Shum, MD; Padmaja Kandula, MD; Amanda Sacks-Zimmerman, PhD
Epilepsy, a condition characterized by recurrent and unprovoked seizures, is among the most commonly diagnosed chronic neurological disorders [1]. Seizures are excessive bursts of electrical activity generated within distinct cortical regions.
Mechanisms of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
M Daniela Orellana Zambrano; Takashi Kitani; Jason J Chang; Nitin Goyal*
The management of Aneurysmal Subarachnoid Hemorrhage (aSAH) in-volves monitoring with clinical exam, vital signs, and transcranial Doppler. “Delayed Cerebral Ischemia” (DCI) is characterized by clinical deterioration and evidence of stroke on imaging that occur beyond the first 72 hours after aSAH.
Integrative analysis of microRNA as blood-based biomarkers in amyotrophic lateral sclerosis
Shijie He; Yaoxinyi Hu; Fangfei Zhang*
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with limited diagnostic and prognostic tools. The identification of minimally invasive biomarkers is critical for early diagnosis, monitoring disease progression, and evaluating therapeutic responses. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression.
Risk of re-bleed in cases of aneurysmal subarachnoid hemorrhage upon external ventricular drain placement: Systematic review
Bader Ali*; Sarah Kawtharani; Elias Horanieh; Houssein Darwish
Aneurysmal Subarachnoid Hemorrhage (aSAH) requires immediate treatment which can lead to better patient outcomes. If acute hydrocephalus is present, a drain should be placed before securing the ruptured aneurysm due to the rapid and devastating outcomes of hydrocephalus.
Assessment of auditory perceptual functions in patients with Parkinson's disease
Sherifa Ahmed Hamed*; Mohamed Ahmed Abd-El Hamed; Amira Mohamed Oseily; Mohamed Kamal Sabra Mohamed
Hearing impairments are manifestations of Parkinson's Disease (PD). We aimed to assess Central Auditory Processing (CAP) functions with PD and their predictors. This was a cross-sectional study. It included 35 patients (male=21; female=14).
Personalized stress detection and reduction in elderly care homes using AI and wearable technology
Tanishk Prakash Dubey*; Amit Kumar Ahuja; BP Mishra; Komal Mishra; Gaurav Bhushan
Stress is a state of increased physical and psychological tension that can significantly affect an individual's health and well-being. Various physiological, psychological, environmental, and emotional factors contribute to stress, and poor management can lead to serious health consequences.
Rewiring the pituitary: Mechanistic insights into cellular flexibility and adaptation
Ribeiro Mariana*; Evangelista Victor
Pituitary cell plasticity has emerged as a critical concept in understanding the adaptability of endocrine function. Historically constrained by technical and conceptual limitations, early studies laid the foundation for identifying multipotential and multihormonal cell populations within the pituitary gland.
"Dancing fingers": A case report of nitrous oxide poisoning with rare upper extremity presentation
Jane Dalisay, DO; Yamandu Rodriguez, MD; Bertrand Liang, MD, PhD*
Nitrous oxide abuse is increasing globally particularly in the young, and manifests as neurologic symptoms typically affecting the lower extremities. We present a case of a patient with significant nitrous oxide abuse who presented with upper extremity symptoms of decreased sensation in the hand, with difficult to control spontaneous movement of the fingers bilaterally ("dancing fingers").
Lumbar neurofibroma: Etiology, clinical presentation, surgical indications, and surgical technique. A focused view about surgical experience in Viseu-Portugal
Marcel Şincari*; Margarida Conceição; Mark-Daniel Şincar
Lumbar neurofibroma is a benign neoplasm that originates from peripheral nerves, specifically from Schwann cells. While it can occur at various anatomical sites, its manifestation in the lumbar region has specific clinical and neurosurgical aspects, which are of great relevance for accurate diagnosis and effective treatment.
Cystic meningiomas, literature review and case reports: Nauta classification modification
Marcel Şincari*; Margarida Conceição; Mark-Daniel Şincari
Meningiomas of central nervous system are common lesion, but among them the cystic meningiomas are very rare tumors. We report two cases of cystic meningioma successfully treated and we propose the modification of the widely used Nauta classification of cystic meningiomas.
Cross-modal audio-visual rehabilitation in unilateral cochlear implanted patients: A pilot study
Francesco Lazzerini*; Luca Bruschini; Luca Baldassari; Francesca Forli; Stefano Berrettini
For many hearing-impaired individuals, even with the aid of Hearing Aids (HAs) or Cochlear Implants (CIs), one of the most demanding tasks remains understanding speech in noise, which is closely tied to spatial hearing. Recent research has highlighted the significant advantages of integrating information from various sensory modalities, a phenomenon known as cross-modal stimulation.